Glomerular involvement in diabetes may be classified based on the type of glomerular involvement.
Parameters:
(1) thickness of glomerular basement membrane (GBM) in electron microscopyin microns by sex
(2) mesangial expansion in percent
(3) Kimmelstiel-Wilson lesion (mesangial nodule)
(4) percent of glomeruli showing global glomerular sclerosis
GBM Thickness |
Mesangial Expansion |
Kimmelstiel Wilson lesion |
Glomerular Sclerosis |
Class |
increased (see below) |
<= 25% |
0 |
<= 50% |
I |
NA |
mild and > 25% |
0 |
<= 50% |
IIa |
NA |
severe and > 25% |
0 |
<= 50% |
IIb |
NA |
NA |
>= 1 |
<= 50% |
III |
NA |
NA |
NA |
> 50% |
IV |
GBM |
Sex |
Age |
Increased? |
<= 395 µm |
F |
NA |
no |
> 395 µm |
F |
NA |
yes |
<=430 µm |
M |
>= 9 years |
no |
> 430 µm |
M |
>= 9 years |
yes |
NA |
M |
< 9 years |
NA |
Specialty: Nephrology