Diabetic hepatosclerosis (DH) is a rare complication of type 1 diabetes mellitus.
Clinical features:
(1) long-standing diabetes with microangiopathy involving multiple organs
Histologic findings in the liver:
(1) dense perisinusoidal fibrosis with basement membrane formation (capillarization of the sinusoids), with basement membrane components (laminin, type IV collagen) by immunohistochemistry
(2) hyaline arteriolosclerosis
(3) absence of cirrhosis
Laboratory findings:
(1) variable elevation in serum alkaline phosphatase
Other conditions associated with capillarization of the sinusoids:
(1) alcoholic hepatitis
(2) viral hepatitis
(3) non-alcoholic steatohepatitis
(4) cirrhosis
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