Diabetic hepatosclerosis (DH) is a rare complication of type 1 diabetes mellitus.


Clinical features:

(1) long-standing diabetes with microangiopathy involving multiple organs


Histologic findings in the liver:

(1) dense perisinusoidal fibrosis with basement membrane formation (capillarization of the sinusoids), with basement membrane components (laminin, type IV collagen) by immunohistochemistry

(2) hyaline arteriolosclerosis

(3) absence of cirrhosis


Laboratory findings:

(1) variable elevation in serum alkaline phosphatase


Other conditions associated with capillarization of the sinusoids:

(1) alcoholic hepatitis

(2) viral hepatitis

(3) non-alcoholic steatohepatitis

(4) cirrhosis


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