Integrilin (eptifibatide) is an inhibitor of the platelet glycoprotein IIb/IIIa receptor. It inhibits platelet aggregation and may be indicated in patients with the acute coronary syndrome.


dosing body weight in kg =

= MIN(body weight in kilograms, 121)

Serum Creatinine

IV Bolus Loading Dose

Continuous Infusion Dose

< 2 mg/dL

180 µg per kg dosing BW

2.0 µg per kg per minute

2.0 to 4.0 mg/dL

180 µg per kg dosing BW

1.0 µg per kg per minute

> 4 mg/dL

not indicated

not indicated



• The bolus is given immediately upon making the diagnosis.

• The continuous infusion is started right after administering the bolus.


Drug solutions available in 100 mL vials:

(1) 2 mg/mL (200 mg per vial)

(2) 0.75 mg/mL (75 mg per vial)


Duration of infusion:

(1) acute coronary syndrome: until hospital discharge or CABG surgery, up to 72 hours. The infusion should be discontinued prior to CABG surgery.

(2) percutaneous coronary intervention (PCI): until hospital discharge or for 18-24 hours after the PCI, up to 96 hours


In addition patients are often treated with both:

(1) aspirin 160-325 mg po per day

(2) heparin


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