Description

Epoprostenol sodium (Flolan, Glaxo Smith Kline) is used to treat patients with pulmonary hypertension. It is a naturally occurring prostaglandin that is a potent vasodilator.


 

The drug is distributed in 0.5 and 1.5 mg vials. Each is reconstituted with 5 mL sterile diluent.

Final Con-centration

0.5 mg vial

1.5 mg vial

Fluid to Withdraw

Volume to 100 mL

3,000 ng/mL

1

0

3

97

5,000 ng/mL

1

0

5

95

10,000 ng/mL

2

0

10

90

15,000 ng/mL

0

1

5

95

 

infusion rate in mL per hour =

= (dose in ng/kg/min) * (body weight in kg) * (60 minutes per hour) / (final concentration in ng/mL)

 

A patient who receives epoprostenol sodium long term may require a higher final concentration than the 15,000 ng/mL.

 


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