Epoprostenol sodium (Flolan, Glaxo Smith Kline) is used to treat patients with pulmonary hypertension. It is a naturally occurring prostaglandin that is a potent vasodilator.
The drug is distributed in 0.5 and 1.5 mg vials. Each is reconstituted with 5 mL sterile diluent.
Final Con-centration
0.5 mg vial
1.5 mg vial
Fluid to Withdraw
Volume to 100 mL
3,000 ng/mL
1
0
3
97
5,000 ng/mL
1
0
5
95
10,000 ng/mL
2
0
10
90
15,000 ng/mL
0
1
5
95
infusion rate in mL per hour =
= (dose in ng/kg/min) * (body weight in kg) * (60 minutes per hour) / (final concentration in ng/mL)
A patient who receives epoprostenol sodium long term may require a higher final concentration than the 15,000 ng/mL.
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