Baker and Fraser identified factors that may impact the quality of a life (QOL) for a patient following graft-versus-host disease. These can help to identify a patient who may benefit from closer monitoring and more aggressive management. The authors are from the University of Minnesota and Royal Children's Hospital in Queensland, Australia.


Patient selection: history of acute GVHD after an hematopoietic cell transplant (HCT)


Factors impacting the patient's quality of life:

(1) chronic graft-versus-host disease, especially if active

(2) long-term sequelae of GVHD, especially if significant

(3) older age at the time of HCT (> 25 years of age)

(4) lower socioeconomic status

(5) lower level of education

(6) unrelated donor for the HCT

(7) poor social support

(8) shorter interval since the HCT (< 5 years)


A patient without chronic GVHD and without significant long-term sequelae can show a quality of life comparable to peers in the general population and are able to return to work.


A person with active chronic GVHD, significant long-term sequalae and other factors may have a very poor quality of life with significant disabilities.


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