A patient who is subjected to repeated plasmapheresis may become depleted in a number of plasma proteins.
Risk factors for protein depletion:
(1) repeated plasmapheresis with plasma replaced by crystalloid, albumin or small amounts of fresh frozen plasma
(2) pre-existing or concurrent malnutrition
(3) other sources of protein loss (protein losing enteropathy, burns, etc)
(4) increased catabolic state
(1) low serum albumin and total protein
(2) abnormal PT and PTT
(3) low serum immunoglobulins
(4) low oncotic pressure
(4) complications associated with inadequate transport proteins
Plasmapheresis is often done to remove antibodies causing disease. Unfortunately loss of desirable immunoglobulins occurs as well.
(1) pre-existing coagulopathy
(2) heart failure
(3) immunosuppressive medications
To read more or access our algorithms and calculators, please log in or register.
Specialty: Clinical Laboratory, Hematology Oncology, Immunology/Rheumatology