The Definition of Remission in Systemic Lupus Erythematosus (DORIS) gives criteria for various nuances of the term remission. It was developed by a large international task force.
Patient selection: systemic lupus erythematosus
Parameters:
(1) SLEDAI-2K score (from 0 to 105)
(2) serologic activity (high serum titer of antibodies to double-stranded DNA with low serum C3 concentration)
(3) glucocorticoid therapy (in mg prednisone per day)
(4) immunosuppressive therapy
(5) antimalarial drug therapy
SLEDAI-2K
Serologic Activity
Steroid Therapy
Immuno-Suppress Rx
Anti-Malarial Rx
Designation
0
no
no
no
+/-
complete remission off therapy
0
yes
no
no
+/-
clinical remission off therapy
0
no
+/- 1-5 mg/day
+/-
+/-
complete remission on therapy
0
yes
+/- 1-5 mg/day
+/-
+/-
clinical remission off therapy
where:
• SACQ = serologically active and clinical quiescent = clinical remission
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