Description

The Definition of Remission in Systemic Lupus Erythematosus (DORIS) gives criteria for various nuances of the term remission. It was developed by a large international task force.


Patient selection: systemic lupus erythematosus

 

Parameters:

(1) SLEDAI-2K score (from 0 to 105)

(2) serologic activity (high serum titer of antibodies to double-stranded DNA with low serum C3 concentration)

(3) glucocorticoid therapy (in mg prednisone per day)

(4) immunosuppressive therapy

(5) antimalarial drug therapy

 

SLEDAI-2K

Serologic Activity

Steroid Therapy

Immuno-Suppress Rx

Anti-Malarial Rx

Designation

0

no

no

no

+/-

complete remission off therapy

0

yes

no

no

+/-

clinical remission off therapy

0

no

+/- 1-5 mg/day

+/-

+/-

complete remission on therapy

0

yes

+/- 1-5 mg/day

+/-

+/-

clinical remission off therapy

 

where:

SACQ = serologically active and clinical quiescent = clinical remission


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