Sodium polystyrene sulfonate (SPS, Kayexalate) is given orally to remove potassium from patients with hyperkalemia. It may also bind other orally-administered drugs, resulting in reduced intestinal absorption and lower efficacy.
Sodium polystyrene sulfonate is an ion-exchange resin. It may bind drugs as well as cations.
The problem can be resolved by increasing the time interval between the taking of SPS and other orally-administered medications.
Patient Selection
Time Interval Between SPS and Other Orally Administered Drugs
gastroparesis, delayed gastric emptying
>= 6 hours
other
>= 3 hours
If therapy with sodium polystyrene sulfonate is necessary but oral therapy cannot be readjusted then delivery as an enema may be considered.
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