Description

Sodium polystyrene sulfonate (SPS, Kayexalate) is given orally to remove potassium from patients with hyperkalemia. It may also bind other orally-administered drugs, resulting in reduced intestinal absorption and lower efficacy.


Sodium polystyrene sulfonate is an ion-exchange resin. It may bind drugs as well as cations.

 

The problem can be resolved by increasing the time interval between the taking of SPS and other orally-administered medications.

 

Patient Selection

Time Interval Between SPS and Other Orally Administered Drugs

gastroparesis, delayed gastric emptying

>= 6 hours

other

>= 3 hours

 

If therapy with sodium polystyrene sulfonate is necessary but oral therapy cannot be readjusted then delivery as an enema may be considered.


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