Sodium polystyrene sulfonate (SPS, Kayexalate) is given orally to remove potassium from patients with hyperkalemia. It may also bind other orally-administered drugs, resulting in reduced intestinal absorption and lower efficacy.

Sodium polystyrene sulfonate is an ion-exchange resin. It may bind drugs as well as cations.


The problem can be resolved by increasing the time interval between the taking of SPS and other orally-administered medications.


Patient Selection

Time Interval Between SPS and Other Orally Administered Drugs

gastroparesis, delayed gastric emptying

>= 6 hours


>= 3 hours


If therapy with sodium polystyrene sulfonate is necessary but oral therapy cannot be readjusted then delivery as an enema may be considered.

To read more or access our algorithms and calculators, please log in or register.