Filtration of pharmaceutical solutions can be an economical means of processing but requires matching of filter characteristics with those of the solution.
Parameters:
(1) solution characteristics
(2) particulate burden
(3) purpose of filtration
(4) volume being processed
Solution Characteristics
Filter Material
aqueous
cellulose
polysulfone
PVDF (polyvinylidene difluoride)
nylon
solvent
teflon
regenerated cellulose
PVDF
protein
PVDF
polysulfone
hydroxyl-modified nylon 66
If the particulate burden is high, then a prefilter should be added.
Purpose
Volume
Pore Size
Filter Selection
sterilization
small
0.22 microns
disc filter
sterilization
large
0.22 microns
cartridge filter
clarification
small
0.8 to 5 microns
disc filter or filter needle
clarification
large
0.8 to 5 microns
cartridge filter
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