Metafuni et al reported a score that can help to identify a hematopoietic cell transplant recipient who is at greater risk risk for certain complications. This can help to identify a patient who may benefit from more aggressive management and who may be treated preemptively. The authors are from multiple institutions in Italy.
Patient selection: hematopoietic cell transplant
Parameters collected 100 days after the transplant:
(1) serum GGT in U/L
(2) serum creatinine in mg/dL
(3) serum cholinesterase in IU/L
(4) serum albumin in g/dL
Parameters
Finding
Points
GGT
< 75 U/L
0
>= 75 U/L
1
creatinine
< 1 mg/dL
0
>= 1 mg/dL
1
cholinesterase
> 4,576 IU/L
0
<= 4,576 IU/L
1
albumin
> 4 g/dL
0
<= 4 g/dL
1
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 4
• The higher the score the greater the risk for significant cGVHD, overall mortality, and transplant related mortality.
Score
Risk Category
2-Year Cumulative Index of Moderate or Severe cGVHD
0 or 1
low
12%
2 or 3
intermediate
20%
4
high
52%
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