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Daratumumab (DARA, Anti-CD38) and Interference with Blood Compatibility Testing

Specialty:

Clinical Laboratory
Obstetrics & Gynecology
Cardiology
Emergency Medicine
Critical Care

Objective:

ICD-10:

Description:

Daratumumab (DARA) is a targeted therapy for multiple myeloma. It is an antibody to CD38, which is present on plasma cells and red blood cells. Therapy with daratumumab can cause an interference with blood compatibility testing if the drug binds to the reagent red cells of the panel used for antibody testing.

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