Dallas Steatosis Index (DSI)

Description

McHenry et al reported the Dallas Steatosis Index (DSI) to identify a patient at risk for nonalcoholic fatty liver disease (NAFLD). The authors are from Washington University and University of Texas Southwestern Medical Center.

Patient selection: adult from 18 to 65 years of age (from the Dallas Heart Study)

NAFLD: liver fat >= 5.5%, excluding greater than moderate alcohol intake

Parameters:

(1) sex

(2) age in years

(3) diabetes mellitus

(4) blood glucose in mg/dL

(5) known hypertension

(6) race or ethnicity

(7) serum triglyceride in mg/dL

(8) serum ALT in IU/L

(9) body mass index (BMI) in kg per square meter

Parameter	Finding	Points
sex and age	age >= 50 and female	0.316
	other	0
known diabetes	no	0.02 * (blood glucose)
	yes	2.4
known hypertension	no	0
	yes	0.3
race ot ethnicity	Hispanic, Asian or other	0.5
	non-Hispanic white or black	0
serum triglycerides		LN(triglycerides)
ALT	< 13.5 IU/L	0
	13.5 to 19.49 IU/L	0.4
	19.5 to 40 IU/L	1.1
	> 40 IU/L	1.5
BMI and race	black and BMI < 25	0
	black and BMI 25-27.49	-0.2
	black and BMI 27.5-34.9	0.8
	black and BMI 35-37.49	0.8
	black and BMI >= 37.5	1.8
	not black; BMI < 25	0
	not black; BMI 25-27.49	0.7
	not black; BMI 27.5-34.9	1.4
	not black; BMI 35-37.49	1.9
	not black; BMI >= 37.5	2.6

DSI probit =

= SUM(points for all of the parameters) - 9.4

probability of NAFLD =

= 1 / (1 + EXP((-1) * (DSI probit))

Performance:

• The area under the ROC curve is 0.82.

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