medical decision support medical decision support
Sign In

D-Dimer to Fibrinogen Ratio (DFR) in a Patient Undergoing a Percutaneous Coronary Intervention (PCI)

Description

Bai et al reported the significance of the D-dimer to fibrinogen ratio in patients undergoing a percutaneous coronary intervention for coronary artery disease. The ratio can help to identify a patient who may benefit from more aggressive management. The authors are from Zhengzhou University, Henan University of Science and Technology and the Key Laboratory of Cardiac Injury and Repair of Henan Province in China.


Patient selection: coronary artery disease after percutaneous coronary intervention

 

Outcome: all-case or cardiac mortality over follow-up (1 to 6 years)

 

Specimen: fasting blood prior to PCI

 

Parameters:

(1) D-dimer concentration in mg/L (normal reference range 0 to 0.3)

(2) plasma fibrinogen concentration in g/L (normal reference range 2-4 g/L)

 

D-dimer to fibrinogen ratio = DFR =

= (D-dimer concentration) / (fibrinogen concentration)

 

Interpretation:

• A ratio >= 0.52 is associated with increased all-cause and cardiac-specific mortality.

• A ratio >= 0.52 has an all-cause mortality of 6.6% vs 2.4% for a lower ratio.

• The hazard ratio is 1.7 for all-cause mortality.


To read more or access our algorithms and calculators, please log in or register.

Specialty