Klijanienko et al list cytologic features associated with a high-risk primary neuroblastic tumor. The authors are from Institut Curie in Paris, France.
High risk cytologic features:
(1) no or few differentiating/mature cells (poorly differentiated)
(2) predominantly neuroblastic component (stroma poor)
(3) mitosis-karyorrhexis index (MKI) > 2%
High risk tumors are usually MYCN amplified (by FISH or PCR)
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Specialty: Hematology Oncology
