A pronormoblast infected with parvovirus B19 shows a number of cytologic features.
Cytologic features in a pronormoblast infected with paravovirus B19:
(1) giant size (diameter usually 25 to 32 microns)
(2) large, eosinophilic intranuclear inclusion
(3) cytoplasmic vacuolization
(4) cytoplasmic pseudopods ("dog ear" projections)
Confirmatory tests:
(1) immunoperoxidase staining
(2) electron microscopy
(3) PCR
Exclusion: other DNA viruses
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Specialty: Infectious Diseases, Pedatrics, Clinical Laboratory
