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Cytokine Storm Associated with TGN1412 (Anti-CD28 Monoclonal Antibody)

Specialty:

Immunology/Rheumatology

Objective:

ICD-10:

Description:

A clinical syndrome mimicking the systemic inflammatory response syndrome (SIRS) occurred in volunteers given the anti-CD28 monoclonal antibody TGN1412. This was associated with the sudden release of multiple cytokines, termed a "cytokine storm".

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