A cutaneous pseudolymphoma may develop at the site of vaccination months or years after the event.
Clinical features:
(1) Skin lesion at the site of a vaccination.
(2) Biopsy of the lesion shows a dense lymphoid infiltrate in the dermis and possibly subcutaneous tissue.
(3) Evaluation of the lesion shows a polyclonal proliferation of T and B cell lymphocytes.
(4) Aluminum deposits identified in the histologic sections and/or evidence of aluminum hydroxide used as an adjuvant in the vaccine used.
Diffferential diagnosis:
(1) cutaneous lymphoma developing at the site
(2) pseudolymphoma from another cause (such as a bug bite)
(3) other kind of lymphoid infiltrate
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Specialty: Infectious Diseases, Pharmacology, clinical
ICD-10: ,
