A cutaneous pseudolymphoma may develop at the site of vaccination months or years after the event.


Clinical features:

(1) Skin lesion at the site of a vaccination.

(2) Biopsy of the lesion shows a dense lymphoid infiltrate in the dermis and possibly subcutaneous tissue.

(3) Evaluation of the lesion shows a polyclonal proliferation of T and B cell lymphocytes.

(4) Aluminum deposits identified in the histologic sections and/or evidence of aluminum hydroxide used as an adjuvant in the vaccine used.


Diffferential diagnosis:

(1) cutaneous lymphoma developing at the site

(2) pseudolymphoma from another cause (such as a bug bite)

(3) other kind of lymphoid infiltrate


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