Antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis may show a number of skin findings.
ANCA-associated vasculitis include:
(1) granulomatosis with polyangiitis (GPA)
(2) microscopic polyangiitis (MPA)
(3) eosinophilic granulomatosis with polyangiitis (EGPA)
Cutaneous manifestations may include:
(1) petechiae and/or purpura
(2) painful or tender skin lesions
(3) maculopapular skin rash
(4) pruritus
(5) ulceration
(6) livedo reticularis or racemosa
(7) gangrene
(8) splinter hemorrhage
(9) cutaneous infarct
(10) nontender skin nodules
Skin biopsy (if taken deep enough to include small arteries) may be diagnostic.
A patient with skin lesions is more likely to have systemic signs of the vasculitis such as alveolar hemorrhage or glomerulonephritis.
