Patient selection: systemic lupus erythematosus (SLE)
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SLEDAI-2K Score During Annual Visits
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Number of Annual Visits
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Designation
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0
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in 3 annual visits
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clinical quiescent (CQD)
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1
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in 1 or more annual visits
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minimal disease activity (MDA)
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>= 2
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in >= 2 annual visits
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chronic active (CAD)
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>= 2
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in 1 out of 3 annual visits
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relapsing-remitting (RRD)
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Alternatively:
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SLEDAI-2K Score in 3 Annual Visits
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Designation
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0 in all 3 visits
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clinical quiescent (CQD)
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1 in >= 1 with no >= 2 visits
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minimal disease activity (MDA)
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>= 2 in 1 visit
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chronic active (CAD)
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>= 2 in >= 2 visits
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relapsing-remitting (RRD)
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A flare was defined as an increase in SLEDAI-2K >= 4 since the previous visit.
Criteria for minimal disease activity - all of the following:
(1) SLEDAI-2K score 1
(2) excluding serology (anti-nuclear antibodies and complement)
(3) with or without antimalarial medication
(4) with or without immunosuppressive drugs (not exceeding maximum recommended dose)
(5) with or without low dose prednisone (<= 5 mg per day)
The SLEDAI-2K of 1 point could be seen with one of the following:
(1) fever (1 point)
(2) thrombocytopenia (platelet count < 100,000 per µL; 1 point)
(3) leukopenia (WBC count < 3,000 per µL; 1 point)
