Patient selection: age from 18 to 75 years of age
Above normal weight: body mass index >= 25 kg per square meter
Criteria:
(1) systolic blood pressure < 130 mm Hg
(2) no blood pressure lowering medications
(3) waist-to-hip ratio < 1.03 for a male and < 0.95 for a female
(4) no self-reported diabetes mellitus
Additional a priori definitions:
(1) absence of metabolic syndrome by the NCEATP-III criteria
(2) HOMA-IR < 2.5
(3) desirable findings:
(3a) vital signs: systolic blood pressure < 130 mm Hg; diastolic blood pressure < 85 mm Hg
(3b) waist measurement: <= 102 cm male or <= 88 cm for a female
(3c) laboratory measures: fasting glucose < 100 mg/dL, HbA1c < 5.7%, serum triglyceride < 150 mg/dL, total cholesterol < 240 mg/dL, HDL-C < 40 mg/dL for male or < 50 mg/dL for female,
(3d) not taking: blood pressure, lipid or glucose lowering medications
