Tuncer et al listed criteria for describing the clinical outcome for a patient following therapy for thrombotic thrombocytopenic purpura-hemolytic uremic syndrome (TTP-HUS). The authors are from the University of Alabama at Birmingham.


Therapy consisted of therapeutic plasma exchange.



(1) platelet count

(2) serum LDH

(3) death

(4) duration of response


Criteria for response #1 - both of the following for >= 2 days after completing plasma exchange:

(1) platelet count >= 150,000 per µL (lower limit of normal reference range)

(2) serum LDH < 350 IU/L (upper limit of the normal reference range)


Criteria for response #2:

(1) clinically stable

(2) discharged with a platelet count < 150,000 per µL

(3) followup platelet count >= 150,000 per µL

(4) I am assuming that the LDH is normal


Criteria for nonresponse:

(1) failure to achieve a response (as defined above)

(2) death


Criteria for remission: persistence of response during the followup period, with no need for additional therapy


Criteria for relapse: new episode of TTP-HUS >= 4 weeks after obtaining an initial response


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