Therapy consisted of therapeutic plasma exchange.
Parameters:
(1) platelet count
(2) serum LDH
(3) death
(4) duration of response
Criteria for response #1 - both of the following for >= 2 days after completing plasma exchange:
(1) platelet count >= 150,000 per µL (lower limit of normal reference range)
(2) serum LDH < 350 IU/L (upper limit of the normal reference range)
Criteria for response #2:
(1) clinically stable
(2) discharged with a platelet count < 150,000 per µL
(3) followup platelet count >= 150,000 per µL
(4) I am assuming that the LDH is normal
Criteria for nonresponse:
(1) failure to achieve a response (as defined above)
(2) death
Criteria for remission: persistence of response during the followup period, with no need for additional therapy
Criteria for relapse: new episode of TTP-HUS >= 4 weeks after obtaining an initial response
