Theodosiou et al reported criteria for quickly excluding significant bacteremia in a pediatric patient. Exclusion of significant bacteremia can expedite care and improve efficiency. The authors are from Portsmouth Hospital in England.

Patient selection: febrile pediatric patient < 16 years of age


Criteria for excluding significant bacteremia:

(1) otherwise well-appearing, without features of sepsis

(2) no comorbidities

(3) negative blood culture after 24 hours of incubation

(4) no objection by the clinician



The rule assumes that the blood cultures are collected properly with sufficient volume.


A pediatric patient meeting the criteria can be discharged and/or parenteral antibiotics can be discontinued.

To read more or access our algorithms and calculators, please log in or register.