Criteria of the Japanese Study Group for Rare Intractable Skin Diseases to Identify a Patient with Juvenile or Dystrophic Epidermolysis Bullosa

 

Clinical criteria:

(1) onset at birth

(2) blisters form readily on the skin and mucous membrane following gentle mechanical stimulation

(3) exclusion of other blistering diseases

(4) lesions resolve with atrophy or scar formation

 

Histologic criteria:

(1) subepidermal blister formation (not intraepidermal)

 

Diagnosis

 

Patient Population	Clinical Criteria	Histologic Criteria
neonate or infant	1, 2 and 3	present
adult	1, 2, 3 and 4	present

 

Once epidermolysis bullosa is identified, further criteria are used to determine the type (see next section).