Juvenile or dystrophic epidermolysis bullosa can be identified when certain clinical and histologic features are present. The authors are from the Japanese Study Group for Rare Intractable Skin Diseases.


Clinical criteria:

(1) onset at birth

(2) blisters form readily on the skin and mucous membrane following gentle mechanical stimulation

(3) exclusion of other blistering diseases

(4) lesions resolve with atrophy or scar formation


Histologic criteria:

(1) subepidermal blister formation (not intraepidermal)




Patient Population

Clinical Criteria

Histologic Criteria

neonate or infant

1, 2 and 3



1, 2, 3 and 4



Once epidermolysis bullosa is identified, further criteria are used to determine the type (see next section).


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