The Japanese Society of Thrombosis and Hemostasis (JSTH) has published criteria for the diagnosis of Disseminated Intravascular Coagulation (DIC). This recognizes 3 clinical types.
Patient selection: suspected DIC
Initial triage:
(1) hematopoietic disorder
(2) infectious disease
(3) all other disorders ("basic")
The workup of the patient involves:
(1) establishing the nature of the underlying disorder
(2) the presence or absence of liver failure
(3) a hemostasis test panel
The hemostasis test panel may include:
(1) PT and aPTT
(2) platelet count
(3) fibrinogen
(4) fibrin-related marker (fibrin degradation product, D-Dimer, other)
(5) antithrombin III
(6) "hemostatic molecular markers": soluble fibrin, thrombin-antithrombin complexes, plasmin-plasmin inhibitor complex, soluble fibrin monomer complex, other
