The Japanese Society of Thrombosis and Hemostasis (JSTH) has published criteria for the diagnosis of Disseminated Intravascular Coagulation (DIC). This recognizes 3 clinical types.

Patient selection: suspected DIC


Initial triage:

(1) hematopoietic disorder

(2) infectious disease

(3) all other disorders ("basic")


The workup of the patient involves:

(1) establishing the nature of the underlying disorder

(2) the presence or absence of liver failure

(3) a hemostasis test panel


The hemostasis test panel may include:

(1) PT and aPTT

(2) platelet count

(3) fibrinogen

(4) fibrin-related marker (fibrin degradation product, D-Dimer, other)

(5) antithrombin III

(6) "hemostatic molecular markers": soluble fibrin, thrombin-antithrombin complexes, plasmin-plasmin inhibitor complex, soluble fibrin monomer complex, other

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