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Criteria of the International Myeloma Working Group for Non-IgM MGUS (Non-IgM Monoclonal Gammopathy of Undetermined Significance, IgA or IgG Monoclonal Gammopathy of Undetermined Significance)

Description

The International Myeloma Working Group reported criteria for making the diagnosis of Monoclonal Protein of Undetermined Significance involving immunoglobulins other than IgM (IgA, IgD, IgG).


Non-IgM immunoglobulins: IgA, IgD, IgE, IgG

 

Criteria for non-IgM MGUS - all of the following:

(1) non-IgM monoclonal protein, with concentration < 3 g/dL (30 g/L)

(2) lymphoplasmacytic infiltrate of the bone marrow < 10%

(3) no evidence of a clinical effect caused by the disorder (absence of anemia, hypercalcemia, renal insufficiency, bone lesions)


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