The International Myeloma Working Group reported criteria for making the diagnosis of IgM MGUS (IgM Monoclonal Protein of Undetermined Significance).

Criteria for IgM MGUS - all of the following:

(1) IgM monoclonal protein, with concentration < 3 g/dL (30 g/L)

(2) lymphoplasmacytic infiltrate of the bone marrow < 10%

(3) no evidence of a clinical effect from the disorder (absence of anemia, constitutional symptoms, hyperviscosity, lymphadenopathy, hepatosplenomegaly)

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