The International Bladder Cancer Group (IBCG) listed criteria for progression of a nonmuscle invasive bladder cancer. The authors are from multiple hospitals in Europe and North America.
Patient selection: initial bladder cancer without muscle invasion (in situ or invasion into lamina propria)
Criteria for progression:
(1) increase in T code (into lamina propria if Tis, into muscle or beyond)
(2) presence of metastases to lymph nodes
(3) distant metastases (M1)
(4) increase in grade (from low grade to high grade)
where:
• The development of nodal or distant metastases without current muscle invasion or high grade tumor may indicate underdiagnosis in the initial exam.
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