Criteria for significant mucocutaneous bleeding - one or more of the following:
(1) recurrent nose bleeds requiring medical treatment and/or causing anemia
(2) oral cavity bleeding with one or more of the following:
(2a) lasting for at least one half hour
(2b) restarting over the next 7 days
(2c) requiring medical treatment
(3) skin laceration bleeding with one or more of the following:
(3a) lasting for at least one half hour
(3b) restarting over the next 7 days
(3c) requiring medical treatment
(4) menorrhagia requiring medical attention and/or leading to anemia
(5) prolonged bleeding associated with or following a dental extraction or other oral surgery
(6) spontaneous gastrointestinal hemorrhage unexplained by local cause (ulcer, portal hypertension) requiring medical attention and/or leading to anemia
(7) prolonged bleeding from other skin or mucous membrane surfaces (eye, ear, respiratory tract, genitourinary tract) requiring medical treatment
