(2) compatible liver biopsy (duct lesion with a mononuclear infiltration affecting the bile duct epithelium with or without a granulomatous reaction in connection with a bile duct or an atypical proliferation)
Minor criteria:
(1) pruritis with need of medications
(2) jaundice with normal clotting factors
(3) serum alkaline phosphatase level >= 2 times the upper limit of normal
(4) serum IgM concentration > 2.8 g/L
(5) abnormal Schirmer test (for tear production, with < 10 mm secretion in 5 minutes)
Major Criteria
Minor Criteria
Diagnosis
2
>= 2
definite PBC
1
>= 4
definite PBC
2
NA
probable PBC
1
>= 2
probable PBC
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