Swenerton et al listed criteria for bone involvement by metastatic breast cancer and its response to therapy. The authors are from the University of Texas Houston M.D. Anderson Cancer Center.
Number of Lesions on Seen X-Ray or Bone Scan
Involvement
0
absent
1 or 2
minimal
3 to 5
moderate
6 or more
extensive
Findings After Treatment
Response to Treatment
healing of all radiological lesions with normalization of bone scan
complete
reduction in symptoms, number of lesions or size; sclerosis of lytic lesions
partial
no change in lesions or symptoms
stable
development of new lesions or increase in size of any lesion by >= 25%
progression
where:
• Criteria for progression are not given for bone in Table 3 but are taken from the general criteria.
• Symptoms are not considered for all of the treatment responses.
The presence of pathologic fractures does not necessarily indicate progression.
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