Criteria – Skin Findings:
(1) Bullae or erosions are present over > 20% of body surface area, OR > 3 different anatomic areas are involved.
(2) Bullae or erosions develop on an erythematous base.
(3) Skin is tender within 48 hours of onset of rash.
(4) Non-sun-exposed skin affected.
(5) Mucous membrane involvement frequent.
(6) Skin peels of in sheets > 3 cm in diameter (i.e., not just erythema and desquamation as is seen in exfolliative erythroderma)
(7) A skin biopsy taken within 48 hours of onset shows basal necrosis, compatible with drug-induced toxic epidermal necrolysis.
Criteria – Other Findings:
(1) Fever (threshold temperature not given)
Criteria - Exclusions:
(1) Staphylococcal scalded skin syndrome excluded.
