Engraftment was defined as a neutrophil count >= 500 per µL for 2 consecutive days.
Onset of syndrome: within 96 hours of engraftment
Major criteria:
(1) temperature >= 38.3°C AND no identifiable source of infection
(2) erythroderma involving > 25% of body surface area AND rash not due to a medication
(3) noncardiogenic pulmonary edema with hypoxia and diffuse pulmonary infiltrates
Minor criteria:
(1) hepatic dysfunction - one or both of the following:
(1a) total serum bilirubin >= 2 mg/dL
(1b) serum transaminase values >= 2 times normal (presumable upper limit of normal)
(2) renal insufficiency (with serum creatinine increased >= 2 times the baseline value)
(3) increase in weight with weight >= 102.5% of baseline
(4) transient encephalopathy AND no other explanation
|
Major
|
Minor
|
Diagnosis
|
|
3
|
>= 0
|
definite
|
|
2
|
>= 1
|
definite
|
where:
• The presence of 1 major AND several minor might mean something but this was not defined in the paper.
