Criteria of Small et al for Response to Therapy in a Patient with a Pancreatic Cancer

 

Parameters:

(1) presence of tumor after therapy

(2) change in the maximum dimension prior to therapy

(3) appearance of new lesions

(4) serum CA 19-9 concentration (if elevated prior to therapy)

 

percent of maximum dimension seen prior to therapy that is present after =

= (diameter of same axis after therapy))/ (diameter of axis prior to therapy) * 100%

Any Tumor After Therapy	Maximum Dimension After Therapy	New Lesions	Response
No	NA	NA	complete
Yes	<= 70%	No	partial
Yes	>= 120%	NA	progressive
Yes	NA	Yes	progressive
Yes	71 - 119%	No	stable

 

Serum CA 19-9 was used as a surrogate marker of tumor burden. This was used if it was elevated prior to therapy.

(1) normalization of serum CA 19-9 indicates a complete response

(2) patients with progressive disease may show a moderate reduction, no change or an increased value