Segal et al listed criteria for the therapeutic response shown by a patient with inivasive candidiasis. These are consensus criteria by the Mycoses Study Group and the European Organization for Research and Treatment of Cancer (EORTC).
Endpoint: survival or death
Reassessment is done at least 4 weeks after the start of treatment (after stopping therapy might be better) to detect relapse. Relapse is best documented by culture. If the previously infected site is inaccessible then observation is maintained for at least 12 weeks.
Signs and Symptoms
Culture or Radiologic Results
Response
complete resolution
accessible sites all negative OR radiologic resolution of inaccessible sites
complete
improvement
accessible sites all negative OR radiologic improvement of inaccessible sites
partial
no or minor improvement
persistent isolation from accessible sites OR no radiologic change in inaccessible sites
stable (unchanged)
worse
persistent isolation from accessible sites OR isolation from new sites OR radiographic worsening of known lesions OR radiographic evidence of new lesions
progression
where:
• Visceral sites may not be accessible for reculture. Radiologic change may be used as a surrogate marker for these sites.
Treatment success was either partial or complete response.
Treatment failure is either stable or progressive disease
To read more or access our algorithms and calculators, please log in or register.
