Preiksaitis and Keay classified patients with posttransplant lymphoproliferative disorder for lymphoid clonality and Epstein-Barr virus (EBV) status. This can help standardize research into this disorder. The authors are from the University of Alberta and the University of Maryland.
Parameters:
(1) histopathologic evidence of lymphoid monoclonality
(2) Epstein-Barr virus status
Lymphoid Clonality
Classification
absent
C0
minor monoclonal (< 50% of cells)
C1
major monoclonal >= 50%
C2
multiclonal or oligoclonal
C3
clonal pattern other than one of those specified above
C4
undetermined
Cx
where:
• Clonality status might not be determined if the specimen was inadequate or testing was not done.
EBV Status
Clonality
Classification
absent
NA
E0
present
not categorized
E1
present
no clonal component identified
E2
present
monoclonal component present
E3
undetermined
NA
Ex
where:
• The EBV status might not be determined if the specimen was inadequate or testing was not done.
• EBV status may be detected using PCR for DNA, in situ hybridization for RNA2, or immunostaining for latent membrane protein.
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