Description

Refractoriness to platelet transfusion is said to occur when a patient's platelet count fails to rise to the level expected following platelet transfusion. While this may be due to several possible mechanisms, a refractory patient who has received several prior platelet transfusions is often assumed to be alloimmunized. This requires selection of platelet donors who have HLA antigens compatible with the patient's alloantibodies.

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