Netchine et al listed criteria for diagnosing a patient with the Russell-Silver Syndrome. The authors are from multiple institutions in France, Poland and Belgium.
Criteria for Silver-Russell syndrome - both of the following:
(1) prenatal growth retardation
(2) 3 or more of the following:
(2a) postnatal growth retardation
(2b) relative macrocephaly at birth
(2c) prominent forehead during early childhood
(2d) body asymmetry
(2e) feeding difficulties during early childhood (or low postnatal BMI)
where:
• Prenatal growth retardation: birth weight and/or length less than or equal to -2 SD for gestational age.
• Postnatal growth retardation: height less than or equal to -2 SD according to Sempe growth charts at 2 years of age
• Relative macrocephaly: head circumference at birth >= 1.5 SD above the birth weight and/length according to the Usher and McLean charts.
• Low postnatal BMI is less than 2 SD below mean.
