Description

Lux and Osborne classified infantile spasms based on clinical and EEG findings. The authors are from the Royal United Hospital and University of Bath in England, and are associated with the West Delphi Group.


 

Parameters:

(1) presence of infantile spasms

(2) epileptiform on EEG

(3) age of the patient

(4) interictal EEG consistent with infantile spasms

(5) pattern of spasms

(6) hypsarrhythmia on EEG, with or without atypical features

 

Features of West syndrome:

(1) presence of infantile spasms

(2) epileptiform on EEG

(3) age of the patient at onset < 2 years

(4) interictal EEG consistent with infantile spasms

(5) spasms occur in clusters

(6) hypsarrhythmia on EEG

 

Features of infantile spasms without hypsarrhythmia:

(1) presence of infantile spasms

(2) epileptiform on EEG

(3) age of the patient at onset < 2 years

(4) interictal EEG consistent with infantile spasms

(5) spasms occur in clusters

(6) no hypsarrhythmia on EEG

 

Features of infantile spasms single spasm variant (ISSV) with hypsarrhythmia:

(1) presence of infantile spasms

(2) epileptiform on EEG

(3) age of the patient at onset < 2 years

(4) interictal EEG consistent with infantile spasms

(5) spasms do not occur in clusters

(6) hypsarrhythmia on EEG

 

Features of infantile spasms single spasm variant (ISSV) without hypsarrhythmia:

(1) presence of infantile spasms

(2) epileptiform on EEG

(3) age of the patient at onset < 2 years

(4) interictal EEG consistent with infantile spasms

(5) spasms do not occur in clusters

(6) no hypsarrhythmia on EEG

 

The absence of infantile spasms, nonepileptiform EEG, older age at onset, or an interictal EEG not indicative of infantile spasms suggest another diagnosis.

 


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