Leporati et al reported criteria for the diagnosis og IgG4-related hypophysitis. The authors are from the Johns Hopkins University, the University of Pavia and the University of Pisa.
(1) biopsy of the pituitary showing a lymphoplasmacytic infiltrate with > 10 cells per high power field IgG4-positive
(2) sellar mass and/or thickened pituitary stalk on MRI
(3) documentation of IgG4-positiive lesions in other organs
(4) elevated serum IgG4 concentration (> 140 mg/dL)
(5) symptom improvement and shrinkage of pituitary mass following steroid therapy
The diagnosis of IgG4-related hypophysitis can be made by one or more of the following combinations of the criteria:
(1) criterion 1
(2) criteria 2 and 3
(3) criteria 2, 4 and 5
To read more or access our algorithms and calculators, please log in or register.
Specialty: Endocrinology, Clinical Laboratory, Neurology, Immunology/Rheumatology