Larsen et al listed criteria for the diagnosis of the Bladder Pain Syndrome (BPS). These can help to identify these patients and to monitor the response to therapy. The authors are from Herlev Hospital in Denmark.


NOTE: The Bladder Pain Syndrome is a term that replaces Interstitial Cystitis (IC) according to the recommendations of the European Society for the Study of Bladder Pain Syndrome/Interstitial Cystitis (ESSIC).



(1) clinical and cystoscopic score

(2) number of mast cells in a detrusor muscle biopsy cut 3 microns thick and stained using the tryptase method


Clinical and cystoscopic score components:

(1) bladder pain

(2) nocturia

(3) bladder capacity < 500 mL

(4) petechial hemorrhage in the bladder mucosa

(5) fibrosis in the bladder wall








total score =

= SUM(points for all 5 parameters)


The number of mast cells was counted per square mm in biopsies from the detrusor muscle sectioned with a thickness of 3 microns and stained using the tryptase method.


A mast cell count >= 27 per square mm indicates mastocytosis.


According to Figure 1c page 206 a clinical/cystoscopic score of 3 roughly corresponds to a mast cell count of 27 per square mm.


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