Criteria of Lara et al for the Response of Prostate Cancer to Therapy

Description

Lara et al used criteria to describe the response of patients with prostate cancer to chemotherapy. This can help describe the patient's course over time. The authors are from the University of California-Davis at Sacramento and City of Hope Comprehensive Cancer Center in California.

Responses:

(1) clinical, based on clinical symptoms and imaging studies

(2) biochemical

Tumor Measurement	Other	Clinical Response
complete disappearance of all measurable disease	no new lesions or disease-related symptoms	complete response
decrease >= 50% from baseline in the sum of products of perpendicular dimensions in all measureable lesions	no new lesions and with no progression in disease-related symptoms	partial response
50 to 150% from baseline	no new lesions	stable disease
50% increase or a 10 square cm increase in sum of products of all measureable lesions over the smallest sum observed, whichever is smaller	reappearance of any lesion that had disappeared, or the appearance of any new lesion	progressive disease

where:

• The sum of products of perpendicular dimensions appears to be 2-dimensional (since disease progression involves square centimeters).

Serum PSA	Response
normalized	complete biochemical response
decrease >= 50% without normalization	partial biochemical response
50 to 150% of baseline	stable biochemical disease
2 consecutive increases to > 50% above baseline, with baseline > 5 times the upper limit of normal reference range	progressive biochemical disease

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Criteria of Lara et al for the Response of Prostate Cancer to Therapy

Description

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