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Criteria of Kuiper et al for Biochemical Response in a Patient with Primary Biliary Cirrhosis (PBC) Treated with Ursodeoxycholic Acid (Rotterdam Criteria)

Description

Kuiper et al reported criteria for biochemical response to ursodeoxycholic acid (UDCA) therapy in a patient with primary biliary cirrhosis (PBC). This can help to identify a patient who may require more aggressive management. The authors are from the Dutch PBC Study Group.


Patient selection: primary biliary cirrhosis following therapy with ursodeoxycholic acid (UDCA) for a year or more

 

Parameters:

(1) serum total bilirubin in mg/dL (abnormal if above the upper limit of the normal reference range)

(2) serum albumin in g/dL (abnormal if below the lower limit of the normal reference range)

 

Early PBC is associated with both parameters being normal at baseline and after therapy. This group had a survival comparable to the general population.

 

Before Therapy

After Therapy

Biochemical Response

one or both abnormal

both normal

response A

both abnormal

one normal

response B

 

A patient who responds to therapy tends to have a better prognosis than someone who does not.


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