Criteria of Korsten et al for Refractory Pulmonary Sarcoidosis

 

Patient selection: pulmonary sarcoidosis

 

Criteria for refractory disease:

(1) progressive lung disease despite >= 10 mg of prednisolone equivalent for >= 3 months

(2) need for additional disease-modifying anti-sarcoid drugs due to lack of efficacy, adverse effects or drug intolerance

(3) significant impairment (disability) as a result of progressive pulmonary disease

(4) exclusion of treatable complications (such as infection, cardiac disease or pulmonary hypertension) or poor compliance

 

where:

• Additional drugs may include: methotrexate, azathioprine, leflunomide, infliximb, adalimumab, pirfenidone, nintedanib