Jordan et al evaluated cerebral atrophy on CT scans of the brain. The authors are from the Hospital for Special Surgery in New York City, New York Hospital-Cornell Medical Center, Columbia University and other institutions in New York City.
Anatomic areas classified:
(1) lateral ventricles
(2) cortical sulci and fissures
(3) posterior fossa
Ventricular Atrophy
Degree
Grade
prominent (seen at the level of the foramen of Monro or occupy 40-50% of bifrontal and biparietal diameters)
borderline
1
definitely enlarged (occupy 50-60% of bifrontal and biparietal diameters)
moderate
2
marked dilatation (occupy > 60% of bifrontal and biparietal diameters)
severe
3
Sulcal Atrophy
Degree
Grade
sylvian and interhemispheric fissures detectable on contiguous sections; some individual sulci delineated above the level of the lateral ventricles
borderline
1
sylvian and interhemispheric fissures prominent and easily detectable; most convexity sulci easily seen on multiple sections (similar to changes seen in a 50-60 year old)
moderate
2
marked dilatation of sulci (similar to changes seen in a 60-70 year old)
severe
3
Posterior fossa atrophy was defined as 2 or 3 of the following:
(1) readily visible cerebellar folia
(2) definite enlargement of the superior cerebellar cistern
(3) prominent fourth ventricle
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