Jones et al used clinical signs and symptoms to diagnose veno-occlusive disease (VOD) after bone marrow transplantation. The authors are from the Johns Hopkins University.
Criteria for the clinical diagnosis of veno-occlusive disease – all of the following:
(1) onset within 21 days after transplant (day 0 = day of transplantation)
(2) hyperbilirubinemia with serum bilirubin > 2 mg/dL
(3) 2 or 3 of the following clinical findings:
(3b) hepatomegaly, with or without right upper quadrant pain
(3c) unexplained weight gain > 5% above baseline
(4) no other identifiable cause for liver disease present
The diagnosis of VOD was made if:
(1) the patient met the clinical criteria, OR
(2) liver biopsy showed histologic evidence of VOD
Resolution of VOD was defined as when the serum bilirubin was <= 1.4 mg/dL.
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Specialty: Gastroenterology, Toxicology