Hartung et al reported criteria for describing the response to therapy by a pediatric patient with acquired aplastic anemia. The authors are from Children's Hospital of Philadelphia and the University of Pennsylvania.
Patient selection: pediatric patient with acquired aplastic anemia
Parameters:
(1) current clinical status for aplatic anemia
(2) previous history of response to therapy
(3) absolute neutrophil count per µL
(4) platelet count per µL
(5) need for red blood cell and/or platelet transfusions
Current Status
Previous Response
Absolute Neutrophil
Platelet Count
Need for Transfusions
Response
normal or near normal
NA
> 1,500
> 150,000
none
complete
improved
NA
>= 500
>= 20,000
reduced
partial
severe or very severe AA
No
NA
NA
ongoing
no
severe or very severe AA
Yes
NA
NA
ongoing
relapse
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