The cytoplasmic granules within a neutrophil may become larger and more prominent in sepsis or other acute reactive processes. This change is termed toxic granulations.
(1) size of cytoplasmic granules
(2) percent of neutrophils showing toxic granulations
Percent of Neutrophilic Cells with Toxic Granulation
all small and uniform
mostly small with a few larger
some small with some larger
5 to 25%
25.1 to 50%
intermediate with some large
50.1 to 75%
almost all large
• This may be a situation where a score determined by (size) * (percent) would be effective.
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Specialty: Hematology Oncology, Clinical Laboratory