Criteria for hypersegmentation in myeloid series:
(1) neutrophils: >= 6 nuclear lobes
(2) eosinophils: >= 4 nuclear lobes
(3) basophils: >= 4 nuclear lobes
Parameters:
(1) distribution of neutrophils with 5+ nuclear lobes
(2) average number of nuclear lobes per neutrophil
average number of nuclear lobes per neutrophil =
= (total number of nuclear lobes for N neutrophils) / (N neutrophils)
percentage of neutrophils with X nuclear lobes =
= (number of neutrophils with X nuclear lobes) / (total number of neutrophils counted) * 100%
The average number of nuclear lobules is 3.4.
Neutrophils may be considered hypersegmented if the percent of neutrophils with 5 or more nuclei is > 10%.
|
Average Number of Nuclear Lobes
|
Percent of Neutrophils with 6 or More Nuclear Lobes
|
Grade
|
|
<= 5
|
< 5%
|
0
|
|
6 (5.01 to 6.49)
|
5 to 10%
|
1+
|
|
7 (6.5 to 7.49)
|
10.1 to 20%
|
2+
|
|
8 (7.5 to 8.49)
|
20.1 to 50%
|
3+
|
|
9 (>= 8.5
|
> 50%
|
4+
|
