Gubner and Ungerleider developed criteria for left ventricular hypertrophy based on findings in a standard 12-lead ECG.



(1) amplitude for the R wave in lead I

(2) amplitude for the S wave in lead III


voltage sum =

= (amplitude of the R wave in I in mV) + (amplitude of the S wave in III in mV)



• A voltage sum >= 25 mV is indicative of left ventricular hypertrophy.



• According to Farb et al, the coefficient of variation is 5.9%. The test is affected by the placement of the leads and body position.

• In a review by Pewsner, sensitivity range from 5-39% (average 16%) and specificity 80-97% (most 96%).


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