Gerard et al listed criteria for the diagnosis of an attack of multicentric Castleman's disease (MCD). The authors are from Paris VII University, Hopital Saint-Louis Assistance Publique-Hopitaux de Paris, Hopital Purpan (Toulouse) and Hopital Hotel-Dieu, Hopital Cote de Nacre (Caen) in France.


Criteria for an attack of multircentric Castleman's disease:

(1) fever

(2) elevated C-reactive protein (> 20 mg/L) in the absence of an alternative explanation

(3) 3 or more of the following:

(3a) peripheral lymphadenopathy

(3b) splenomegaly

(3c) edema

(3d) pleural effusion

(3e) ascites

(3f) cough

(3g) nasal obstruction

(3h) xerostomia

(3i) skin rash

(3j) jaundice

(3k) autoimmune hemolytic anemia

(3l) central nervous system symptoms


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